But at just one acre, is it worth the steep price?
Beverly Hills Realtor Chad Rogers, former star of Million Dollar Listing, doesn't think so.
"It's my professional opinion that the property is not worth $42 million in the current market," he says, adding that a comparable neighboring property sold a few months ago for $13 million (at $2,680 per square foot).
Aniston's home is priced at $4,200 per square foot.
The large price tag no doubt reflects the amount Aniston put into the renovation. A Beverly Hills insider reports that Aniston was rumored to have dropped quite a bit of cash on upgrades, including a sophistocated security system, including a paparazzi-proof fence.
The Balinese-style home, listed with Jade Mills of Coldwell Banker Previews International, seems to suit the yoga lover with its earthy feel, indoor-outdoor living and tranquil water features: The property has a pool, spa, ponds and fountains. It sits right above Sunset Boulevard, and in the desirable Trousdale Estates area.
Inside, the stone, glass and wood home has 5 bedrooms and 7.5 baths, including two in the master suite. According to Forbes, the master suite originally "his" and "hers" baths but the single Ms. Aniston converted the "his" to a spa room with a sunken spa tub and steam shower.
One of the highlights of the home is the kitchen space, which is slightly odd because doesn't Aniston have a private chef delivering meals to her? Here she's got a main kitchen with such luxuries as a pizza oven with a separate professional catering kitchen where a staff can inconspicuously prepare meals for a party.
"She did an absolutely phenomenal job renovating the original property," says Rogers. "There are very few properties in this area that compare to the aesthetic of Aniston's home. However, when comparing directly to its competition, the asking price of Aniston's home is still a lot higher than other homes in the neighborhood."
Of course, Aniston's star power will help draw attention to the listing, and likely entice some buyers, but Rogers doesn't believe that will be enough.
"At the end of the day, I don't believe it will actually sway a buyer to purchase this home for considerably more than what its worth."